What 90% of people don’t know about cystic fibrosis

CF Patient
Labeled Lungs

CFTR Protein

CFTR Protein Structure
  1. The mRNA travels to the endoplasmic reticulum (ER) and binds with ribosomes to be translated into a protein
  2. Travels to the Golgi apparatus (GA). Proteins, known as chaperones, help shape the protein and add sugars.
  3. Locates to the surface of the cell, and channels ions within the cell membrane
  • 2 cytoplasmic nucleotide-binding domains — NBD1 + NBD2
  • 1 regulatory domain
Structure of a CFTR Protein
  • CFTR channel: channels chloride
  • ORCC: outwardly rectifying chloride channel
  • ENaC: epithelial sodium channels
  • CaCC: Calcium-Dependent Chloride Channel
Channels in a cell membrane

Pathophysiology of Cystic Fibrosis

Have you ever had a copycat as a friend? If you haven’t, it feels like there are literally 2 of you, since a person (your clone) is repeating almost every single movement of yours. In cystic fibrosis, it’s the same concept but with substances, sodium, chloride, and water.

Normal Secretions
Secretions of a CF patient
Secretions in the respiratory airway
  • Metabolomics: the study of molecules
  • Proteomics: the study of proteins
  • Microbiome: genetic material of all the microbes — bacteria, fungi, protozoa, and viruses
  • Pharmacogenomics: the study of how genes affect responses to a drug

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Sanvi Rao

Sanvi Rao

Hey! I’m Sanvi. A 14 year old, who loves a challenge and is super passionate about learning the world’s biggest problems.